Pre-Clinical Services

Protocol design and ethics review

End point outcomes

Tissue culture

• In life study conduct
• In life outcomes
  • Endurance (treadmill)
  • Muscle strength (grip; muscle force)
  • Lung function (plethysmography)
  • Heart function (microechocardiography)
  • Inflammation (caged near infrared imaging)
  • Activity (voluntary running wheel)
  • Coordination (rotarod performance)
  • Blood sampling and lab assays

• Muscle physiology (contraction force)
• Histology, pathology (microscopy)
  • Myofiber size
  • Inflammation
  • Muscle regeneration
  • Fibrosis
  • Myofiber leakage (Evans blue)
  • Others; custom assays
• Biomarker studies (protein, RNA, DNA)
  • Immunostaining, immunohistochemistry
  • Western blot
  • ELISA
  • Mass spec
  • RNA RT-PCR

• In vitro cell bioassays
• Stable isotope labeling
• Primary and immortalized myogenic cells