Pre-Clinical Services

Protocol design and ethics review

End point outcomes

Tissue culture

  • In life study conduct
  • In life outcomes
    • Endurance (treadmill)
    • Muscle strength (grip; muscle force)
    • Lung function (plethysmography)
    • Heart function (microechocardiography)
    • Inflammation (caged near infrared imaging)
    • Activity (voluntary running wheel)
    • Coordination (rotarod performance)
    • Blood sampling and lab assays
  • Muscle physiology (contraction force)
  • Histology, pathology (microscopy)
    • Myofiber size
    • Inflammation
    • Muscle regeneration
    • Fibrosis
    • Myofiber leakage (Evans blue)
    • Others; custom assays
  • Biomarker studies (protein, RNA, DNA)
    • Immunostaining, immunohistochemistry
    • Western blot
    • ELISA
    • Mass spec
    • RNA RT-PCR
  • In vitro cell bioassays
  • Stable isotope labeling
  • Primary and immortalized myogenic cells