Information
The MeCP2 null mouse develops neurological deficits at 3-8 weeks that encompass aspects of the neurological and physical symptoms observed in Rett Syndrome. Clinical presentation manifests as a combination of hindlimb clasping, uneven breathing, tremor, gait, and general malaise that are scored to assess phenotypic severity. The average lifespan of MeCP2-/- mice is 50-60 days. The efficacy of candidate therapeutics for Rett Syndrome can be assessed using this model in combination with plethysmography, grip strength, voluntary wheel, and foot slip functional assessments