Information

C57BL/10-mdx mice were backcrossed to DBA/2J inbred mice for several generations by Jackson Labs, using a speed congenics approach to generate the DBA/2J-congenic strain (DBA/2J-mdx). The skeletal muscle and cardiac phenotype is more severe than that of C57BL/10ScSn-Dmdmdx/J. This may be a useful model for preclinical drug testing. DBA2/J mice are the wild-type controls for this model. We have systematically phenotyped this model at multiple age groups.

Related information

https://www.jax.org/strain/013141 

Coley, W. D., Bogdanik, L., Vila, M. C., Yu, Q., Van Der Meulen, J. H., Rayavarapu, S., . . . Nagaraju, K. (2016). Effect of genetic background on the dystrophic phenotype in mdx mice. Human Molecular Genetics, 25(1), 130-145. doi:10.1093/hmg/ddv460. Publication

Fukada, S., Morikawa, D., Yamamoto, Y., Yoshida, T., Sumie, N., Yamaguchi, M., … Yamamoto, H. (2010). Genetic Background Affects Properties of Satellite Cells and mdx Phenotypes. The American Journal of Pathology, 176(5), 2414–2424. Publication