This strain was generated through n-ethylnitrosourea (ENU) mutagenesis program. It has fewer revertant muscle fibers than the mdx strain in skeletal muscle. These mice exhibit histopathological features similar to mdx including fibrosis, fatty infiltration and necrosis in the diaphragm that progresses with age.

Related information


Chapman, V. M., Miller, D. R., Armstrong, D., & Caskey, C. T. (1989). Recovery of induced mutations for X chromosome-linked muscular dystrophy in mice. Proceedings of the National Academy of Sciences of the United States of America, 86(4), 1292–1296. Publication

Kimura, E., Li, S., Gregorevic, P., Fall, B. M., & Chamberlain, J. S. (2010). Dystrophin Delivery to Muscles of mdx Mice Using Lentiviral Vectors Leads to Myogenic Progenitor Targeting and Stable Gene Expression. Molecular Therapy, 18(1), 206–213. Publication

Danko, I., Chapman, V., & Wolff, J. A. (1992). The Frequency of Revertants in mdx Mouse Genetic Models for Duchenne Muscular Dystrophy. Pediatr Res, 32(1), 128-131.